Antimicrobial host defence peptides: functions and clinical potential
نویسندگان
چکیده
منابع مشابه
Antimicrobial peptides in innate intestinal host defence.
Precursors of alpha-defensin peptides require activation for bactericidal activity. In mouse small intestine, matrilysin colocalized with alpha-defensins (cryptdins) in Paneth cell granules, and in vitro it cleaved the pro segment from cryptdin precursors. Matrilysin-deficient (MAT−/−) mice lacked mature cryptdins and accumulated precursor molecules. Intestinal peptide preparations from MAT−/− ...
متن کاملHost defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections
The rapidly increasing incidence of multidrug-resistant infections and the alarmingly low rate of discovery of conventional antibiotics create an urgent need for alternative strategies to treat bacterial infections. Host defence peptides are short cationic molecules produced by the immune systems of most multicellular organisms; they are a class of compounds being actively researched. In this r...
متن کاملHost defence peptides from invertebrates--emerging antimicrobial strategies.
Cationic antimicrobial (host defence) peptides are found as potent components of the innate immune system of all invertebrates in which they have been investigated. They vary substantially in their amino acid sequences, secondary structures, inducibility, potency and antimicrobial activity spectra. This enormous diversity is providing templates for the design and development of both antibiotic ...
متن کاملFunction and therapeutic potential of host defence peptides.
Cationic host defence (antimicrobial) peptides are an important component of the innate immune systems of a wide variety of plants, animals, and bacteria. Although most of these compounds have direct antimicrobial activities under specific conditions, a greater appreciation for the diversity of functions of these molecules is beginning to develop in the field. In addition to their directly anti...
متن کاملDesign of host defence peptides for antimicrobial and immunity enhancing activities.
Host defense peptides are a vital component of the innate immune systems of humans, other mammals, amphibians, and arthropods. The related cationic antimicrobial peptides are also produced by many species of bacteria and function as part of the antimicrobial arsenal to help the producing organism reduce competition for resources from sensitive species. The antimicrobial activities of many of th...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2020
ISSN: 1474-1776,1474-1784
DOI: 10.1038/s41573-019-0058-8